Articles by Pooja H. Rambhia, MD Candidate, Case Western Reserve University
Spotlight on Immunotherapy: Genetic Makeup of Tumors Informs use of anti-PD-1 drugs for Multiple Cancer Types
By Pooja H. Rambhia, MD Candidate, Case Western Reserve University | 6 October 2017 In News, Science, Treatment
Imagine the powerlessness one must feel after undergoing rigorous treatment for cancer only to find that your tumor is non-responsive. However – new hope may be on the horizon. In May 2017, the U.S. Food and Drug Administration (FDA) granted accelerated approval to Pembrolizumab for treatmentof patients whose cancers possess a genetic mutation in the mismatch repair pathway (mismatch repair deficient, or dMMR) or are microsatellite instability-high (MSI-H). This is the first time the agency approved a cancer treatment based on a common biomarker rather than the location in the body where the tumor originated.
Non-invasive Detection Modalities and Metastatic Risk Stratification for Melanoma: Where Are We Now?
By Pooja H. Rambhia, MD Candidate, Case Western Reserve University | 10 July 2017 In Prevention, Science, Treatment
While dermatologists have advocated for patient education about irregular skin lesions in order to catch melanomas earlier, dermatologists ultimately play the largest role in the detection and excision of abnormal skin lesions via skin biopsy. However, visual recognition and assessment of pigmented skin lesions is limited to the eye of the dermatologist, and can be challenging for even the most experienced clinicians.
Melanoma Clinical Oncology Research: Interview with Dr. Joshua Arbesman
By Pooja H. Rambhia, MD Candidate, Case Western Reserve University | 6 June 2017 In Science, Treatment
As a third year medical student, MD Candidate Pooja Rambhia had the privilege of conducting an elective research year under Dr. Joshua Arbesman’s mentorship at University Hospitals Cleveland Medical Center. Arbesman has a unique role in translational basic science research within the realm of familial melanoma.
Taking Charge of the Skin You’re In: 3 Levels of Melanoma Prevention and Detection
By Pooja H. Rambhia, MD Candidate, Case Western Reserve University | 3 April 2017 In Melanoma Stories, Prevention, Treatment
No healthy person in their twenties expects they’re going to get a call one day telling them they have an invasive nodular melanoma. Despite seeing and hearing of horrible stories about young patients developing cancers, we can’t imagine it’ll happen to us. That element of surprise is exactly what 25-year-old medical student, Alissa Prior, experienced upon hearing her diagnosis.
The Power of Combination Therapies: One Patient’s Road to Remission
By Pooja H. Rambhia, MD Candidate, Case Western Reserve University | 28 February 2017 In Science, Treatment
Metastatic melanoma can be a devastating diagnosis to receive. Just hearing the word cancer for most is terrifying. While the fear is understandable, today new targeted therapies and immunotherapies are delivering new hope for many.
Melanoma Immunotherapy and Precision Medicine — a Medical Student’s Perspective
By Pooja H. Rambhia, MD Candidate, Case Western Reserve University | 20 January 2017 In Science
Malignant melanoma research has provided the perfect opportunity to explore the intersection of immunotherapy and precision medicine, which has greatly transformed melanoma therapeutics in the last decade.