About Melanoma » Melanoma Stories
Dr. David A. Roth is a Vice President at Pfizer in the Oncology Business Unit. Dr. Roth leads Pfizer Oncology’s Early Development Group, a global R&D team that develops all Oncology Business Unit pipeline drugs through the Proof-of-Concept development milestone, with a focus on targeted therapies. His portfolio has included palbociclib, a CDK 4/6 cell cycle inhibitor now in phase 3 development for ER+ breast cancer, which is also the focus of a recent MRA-Pfizer partnership award in melanoma. Prior to entering the biopharmaceutical industry over a decade ago, Dr. Roth was on the full time faculty at Harvard Medical School and Beth Israel Deaconess Medical Center. His research focused on hemostasis and human gene therapy and he had spent nearly 10 years as a hematologist in academic medicine.Read more.
I was 24 when I first noticed a “mark” on my breast. Living a busy life focused mainly on my career, I didn’t even think twice about my health. I felt fine. I didn’t even call it a mole at first because it was just a dot and it had just recently appeared. It was a small dark dot. Almost like the tip of a black Sharpie marker.Read more.
As a pediatric hematologist/oncologist at Children’s Hospital in Boston, Leonard Zon says, “I certainly never expected I would end up working with fish.” Dr. Zon studies a unique organism: the zebrafish. This one and a half inch fish happens to have a gene set that is very similar to the human gene set. Zon is a pioneer in the zebrafish field and chose to model human diseases using this fish because, “the zebrafish embryo is completely clear, providing a ‘real time’ view of all organs and systems as they develop.” With 3,000 tanks in his lab, he has one of the largest aquaria in the world.Read more.
"In 2007, I was diagnosed with Stage II melanoma despite being under the care of a top dermatologist. For several years I had been told the bleeding spot on the bottom of my foot was a wart. After several skin grafts and a difficult physical and emotional recovery, I was horrified to discover the prognosis for advanced stage melanoma had not improved over the past 40 years.Read more.
On May 4, 2012, I took my nine-year-old daughter Alyssa to the dermatologist for a second time. In 2009 they had removed a Spitz nevus from her thigh area. At the time we were told that a Spitz nevus is not harmful, but since they can turn cancerous and since experts have a difficult time differentiating them from melanoma, they are typically removed. This time, we were there for a couple of spots that had grown since she started growth hormones the previous March since she is also short stature. Many spots were checked and okayed, but one of the spots “looked suspicious,” and so they did a biopsy. It was a small red, raised area on her left forearm. We were told at the time that skin cancer doesn’t happen in kids under 13. Alyssa was 9, so it was nothing to really worry about. A few weeks later, the dermatologist called to say it was melanoma.Read more.