Clinical Trials to Watch: Intralesional Therapies for Melanoma
By Kristen Mueller, Ph.D., MRA Scientific Program Director | 8 February 2020 In Science, Treatment
To an outsider, the number of new treatment options for melanoma may seem to be moving at a breakneck pace. Checkpoint immunotherapy and BRAF/MEK inhibitors have greatly improved outcomes for many late-stage melanoma patients, with over 50% of patients on combination ipilimumab/nivolumab still alive after 5 years.
Stage 4 Melanoma, a Vaccine Clinical Trial, and the Power of Family & Faith
“Clinical trials allow you to take advantage of the latest research and experiences from doctors and patients who’re blazing the trails. Clinical trials are also a way for you to help the next person who is going to have to go through this. If you have the opportunity to be part of something that helps others, why wouldn’t you at least try it?”
Melanoma Research Advances – 2019 in Review
During 2019, melanoma research continued its rapid pace of advancement, with FDA approval of a new adjuvant therapy treatment option, several first-in-human clinical trials, and significant progress towards earlier intervention.
2020 Melanoma Mortality Rates Decreasing Despite Ongoing Increase in Incidence
Each January, the American Cancer Society (ACS) releases updated estimates about trends in new cancer cases and deaths in its annual report, Cancer Facts and Figures. This report highlights the estimated incidence (number of new cases), prevalence (number of people alive today with a history of cancer), and survival statistics for...
Approaches to Neoadjuvant Treatment in Melanoma: A Public Workshop Organized by the FDA and MRA
On November 6, 2019, the FDA and the Melanoma Research Alliance co-hosted a public workshop to identify, discuss, and address key issues, challenges and opportunities in the pursuit of neoadjuvant therapies for patients with surgically resectable melanoma. This exciting, half-day workshop brought together clinicians, researchers, regulators, and patient advocates to explore opportunities and discuss challenges in the development of neoadjuvant therapies for melanoma. The workshop took place at National Harbor (outside of Washington, D.C.) with opportunities to participate in person and via simultaneous webcast.
Bob Enrolls in Clinical Trial Testing NeoAdjuvant Therapy for Melanoma
After being diagnosed with Stage 3 melanoma, Bob chose to enroll in a clinical trial at Georgetown University, comparing the effectiveness of treating melanoma with pembrolizumab before or after surgery, what doctors call neo-adjuvant and adjuvant therapy respectively.
MRA is Raising the Treatment Bar
We have made unprecedented progress that is transforming what it means to be diagnosed with melanoma. Today, we have more treatment options than ever before—in fact 12 new options have earned FDA approval since MRA's founding. But, it's still not enough.
Take Control After a Melanoma Diagnosis
You are used to giving the marching orders to your own body, but when cancer steers it in the wrong direction, it can feel like you are no longer in control. Yet this is when it’s most important to take control, stressed melanoma physicians, patients, and advocates at the 2019...
SPORE Grants: Putting Collaboration Front & Center
In medicine, sometimes the biggest and most game-changing advancements come from a single person – who through tireless work – arrives at a true ‘eureka’ moment. This ‘go it alone’ concept is not only reinforced through television and movies, it’s also bolstered in the way the medical community makes research...
Treating Melanoma Patients Before Surgery
Over 90% of patients who have their tumors surgically removed will never see their tumors come back or spread to other sites, but is there a way to prevent recurrence in those patients that will eventually go on to relapse? One approach currently being tested in clinical trials, termed neoadjuvant therapy, is to treat early stage patients with targeted or immunotherapy before surgical removal of their tumor.